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      Math Colloquium - Mathematical Modeling of Cellular Blebbing Dynamics in Rochester

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      January 24, 2020

      Friday  12:00 PM

      1 Lomb Memorial Drive
      Rochester, New York 14623

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      Math Colloquium - Mathematical Modeling of Cellular Blebbing Dynamics

      Mathematical Modeling of Cellular Blebbing Dynamics

      Dr. Wanda Strychalski
      Case Western Reserve University

      Blebs are pressure-driven membrane protrusions that play an important role in cell migration, particularly in 3D environments. A bleb is initiated when the cytoskeleton detaches from the membrane, resulting in the pressure-driven flow of cytosol towards the area of detachment and local expansion of the cell membrane. Recent experiments involving blebbing cells have led to conflicting hypotheses regarding intracellular pressure dynamics. A dynamic computational model of the cell in both two and three dimensions is presented to simulate these experiments, and results show that complex rheology of cytoplasm is essential to explain experimental observations. The model is also used to quantify intracellular pressure dynamics during different mechanisms of bleb initiation. Novel numerical methods developed to simulate cytoplasmic poroelasticity and membrane mechanics are discussed.

      Speaker Bio:
      A western New York native, Wanda Strychalski received her B.S. in Computational Mathematics from Rochester Institute of Technology, M.S. and Ph.D. in Applied Mathematics from the University of North Carolina at Chapel Hill under the direction of Timothy C. Elston and David Adalsteinsson. She is currently an Assistant Professor in the Department of Mathematics, Applied Mathematics, and Statistics at Case Western Reserve University. Her research interests include scientific computing, mathematical biology, and computational cell biology.

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